THE ROLE OF INSULIN RESISTANCE AND ENDOCRINE FACTORS

by

IN THE DEVELOPMENT OF CARDIOVASCULAR RISK IN PATIENTS WITH AGE-ASSOCIATED METABOLIC DISORDERS

Editorial Note

This article was originally published in the journal Zarubezhnaya Meditsina i My in May 2023. The Editorial Board of the International Journal of Interdisciplinary Research approved its republication due to its interdisciplinary relevance to endocrinology, cardiology, metabolic medicine, and clinical gerontology. The text is reproduced with the author’s permission and without substantive modifications compared to the original publication.

Abstract

Insulin resistance represents one of the key pathogenetic mechanisms linking age-associated metabolic alterations with the development of cardiovascular risk. Disturbances of carbohydrate and lipid metabolism, chronic low-grade inflammation, endothelial dysfunction, and age-related hormonal shifts form a multilevel cascade contributing to cardiovascular complications even in the absence of clinically overt diabetes mellitus.
This article presents an integrative analysis of endocrine–cardiovascular mechanisms, conceptualizing insulin resistance as a systemic and potentially modifiable determinant of cardiovascular risk during aging. Pathophysiological pathways, clinical implications,
diagnostic approaches, and preventive and therapeutic strategies aimed at reducing cardiometabolic risk in older populations are discussed.

Keywords:

insulin resistance, metabolic syndrome, endocrine aging, cardiovascular risk, chronic inflammation, endothelial dysfunction

Author: Natalia V. Brailova
ORCID: 0009-0002-2155-411X

International Journal of Interdisciplinary Research
Volume 4, Issue 2 (2023)

Peer Reviewer (Acknowledged): Boris Karsakov
ORCID: 0009-0006-4851-6366

DOI: pending

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THE-ROLE-OF-INSULIN-RESISTANCE-AND-ENDOCRINE-FACTORS

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