CLINICAL AND PATHOPHYSIOLOGICAL PERSPECTIVES
Editorial Note
This article was originally published in the journal Zarubezhnaya Meditsina i My in August 2022.
The Editorial Board of the International Journal of Interdisciplinary Research approved the republication of this work due to its interdisciplinary relevance to cardiology, vascular biology, gerontology, and preventive clinical medicine.
The article is reproduced with the author’s permission and without substantive changes compared to the original publication.
Abstract
Endothelial dysfunction is recognized as one of the key pathophysiological mechanisms of cardiovascular aging and a major contributor to cardiovascular risk in older populations. Age-associated impairment of endothelial function precedes clinically overt cardiovascular disease and plays a decisive role in the progression of arterial hypertension, atherosclerosis, and heart failure. This article analyzes contemporary concepts of endothelial regulation of vascular homeostasis, examines mechanisms underlying age-related endothelial dysfunction, and discusses clinical approaches to assessing endothelial function and strategies for its prevention and correction within cardiovascular disease prevention frameworks
Keywords:
endothelial dysfunction, cardiovascular aging, vascular endothelium, atherosclerosis, arterial hypertension, cardiovascular prevention.
Author: Ekaterina R. Alimova
ORCID: 0009-0005-6128-6641
International Journal of Interdisciplinary Research
Volume 3, Issue 3 (2022)
Peer Reviewer (Acknowledged): Boris Karsakov
ORCID: 0009-0006-4851-6366
DOI: pending
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